The Introduction to the Endocannabinoid System course provides a comprehensive exploration of the naturally occurring lipid signaling system that plays a vital role in regulating physiological functions and maintaining homeostasis. Presented by A/Prof Jonathan Arnold, a leading expert in cannabinoid pharmacology, this course delivers cutting-edge insights into one of the body's most fascinating systems.
This unit delves into the foundational aspects of the endocannabinoid system, covering its structure, function, and therapeutic potential. Key topics include:
- Components of the Endocannabinoid System:
- Endocannabinoids: Anandamide and 2-AG, their synthesis, and degradation.
- Cannabinoid Receptors (CB1 and CB2): Their distribution, roles, and interaction with various physiological processes.
- Enzymes: Key synthetic and catabolic enzymes regulating endocannabinoid levels.
- Functions and Mechanisms:
- Homeostatic roles in analgesia, mood, energy balance, and stress response.
- Retrograde signaling in the brain, modulating neurotransmitter release to maintain cellular balance.
- Extended interactions with other receptors and pathways, including TRPV1 channels and PPARs.
- Therapeutic Implications:
- Relationship between endocannabinoid dysregulation and conditions like chronic pain, epilepsy, PTSD, and neurodegenerative diseases.
- Overview of cannabinoids (THC, CBD) and their mimicking of endocannabinoid actions.
- Insights into synthetic cannabinoids and their development as therapeutic agents.
- Research and Innovations:
- Cutting-edge discoveries, including enzyme inhibitors and positive allosteric modulators.
- Case studies illustrating the system's impact on diseases like Dravet syndrome and Huntington’s disease.
This course equips healthcare professionals with a deep understanding of the endocannabinoid system's pivotal role in health and disease. By integrating theoretical knowledge with real-world applications, participants will gain the skills to explore its potential in therapeutic contexts, ultimately enhancing patient care.
This course is designed for GPs and is also suitable for all degree qualified medical professionals.